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Handbook of Mitochondrial Dysfunction
  • Language: en
  • Pages: 480

Handbook of Mitochondrial Dysfunction

  • Type: Book
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  • Published: 2019-05-15
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  • Publisher: CRC Press

Mitochondria produce the chemical energy necessary for eukaryotic cell functions; hence mitochondria are an essential component of health, playing roles in both disease and aging. More than 80 human diseases and syndromes are associated with mitochondrial dysfunction; this book focuses upon diseases linked to these ubiquitous organelles. Accumulation of mitochondrial DNA damage results in mitochondrial dysfunction through two main pathways. Mutation in mitochondrial DNA causes diseases such as Kearns-Sayre syndrome and Pearson syndrome. Mutation in chromosomal DNA causes diseases such as Parkinson's disease and schizophrenia. These and many other diseases are reviewed in this book. Key Features Presents the detailed structure of mitochondria, mitochondrial function, roles of oxidants and antioxidants in mitochondrial dysfunction. Includes summary of both causes and effects of these diseases. Discusses current and potential future therapies for mitochondrial dysfunction diseases Explores a wide variety of diseases caused by dysfunctional mitochondria.

Derivatives
  • Language: en
  • Pages: 940

Derivatives

It has been the authors' experience that the overwhelming majority of students in MBA derivatives courses go on to careers where a deep conceptual, rather than solely mathematical, understanding of products and models is required. The first edition of Derivatives looks to create precisely such a blended approach, one that is formal and rigorous, yet intuitive and accessible. The main body of this book is divided into six parts. Parts 1-3 cover, respectively, futures and forwards; options; and swaps. Part 4 examines term-structure modeling and the pricing of interest-rate derivatives, while Part 5 is concerned with credit derivatives and the modeling of credit risk. Part 6 discusses computational issues.

The Basics of Biology
  • Language: en
  • Pages: 280

The Basics of Biology

An introduction to biology describes the discipline's history, explains its basic theories and concepts, demonstrates modern methods and research tools, and discusses noteworthy discoveries.

Hoffman and Abeloff's Hematology-Oncology Review E-Book
  • Language: en
  • Pages: 500

Hoffman and Abeloff's Hematology-Oncology Review E-Book

For those preparing for certification or recertification in hematology or oncology, Hoffman and Abeloff's Hematology-Oncology Review is a single-volume source of authoritative, up-to-date exam preparation. This unique question and answer review helps you succeed on today’s board exams with more than 1,000 board-style questions, answers, and rationales; comprehensive coverage of essential exam topics, and online practice tests. Includes 1,000+ board-style questions with answers and rationales explaining both correct and incorrect answers. Covers a broad range of topics compiled by experts in hematology and oncology, including cancer biology and genomics, immunotherapy, hematologic malignancies, solid tumor malignancies, non-malignant hematology, and supportive care. Uniquely designed as both a standalone review and a study companion to Abeloff’s Clinical Oncology and Hematology: Basic Principles and Practice.

Molecular Imaging with Reporter Genes
  • Language: en

Molecular Imaging with Reporter Genes

Reporter genes have been used for several decades to study regulation of gene expression in vivo. However, it was little more than a decade ago that a new class of reporter genes was developed for imaging molecular events within living subjects. By following the interactions of protein molecules, researchers can resolve the complex chemical pathways that living cells utilise. This book focuses on this group of imaging reporter genes, starting with detailed descriptions of all reporter genes from different imaging modalities, including optical, MRI, and radionuclide-based imaging. Key scientists in the field explain how to enhance reporter gene imaging utility through instrumentation and the various applications of this technology. This is the first comprehensive book on all aspects of reporter gene imaging, detailing what is known in the field and future goals for research. Investigators in biomedical sciences, physicians, and the biotechnology and pharmaceutical industries will benefit from topics covered.

Managing Agile Projects
  • Language: en
  • Pages: 229

Managing Agile Projects

Your Hands-On, "In-the-Trenches" Guide to Successfully Leading AgileProjectsAgile methods promise to infuse development with unprecedented flexibility, speed, and valueand these promises are attracting IT organizations worldwide. However, agile methods often fail to clearly define the manager s role, and many managers have been reluctant to buy in. Now, expert project manager Sanjiv Augustine introduces agility "from the manager s point of view, offering a proven management framework that addresses everything from team building to project control. Augustine bridges the disconnect between the assumptions and techniques of traditional and agile management, demonstrating why agility is better a...

Biology and Criminology
  • Language: en
  • Pages: 378

Biology and Criminology

  • Type: Book
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  • Published: 2010-03-17
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  • Publisher: Routledge

Numerous criminologists have noted their dissatisfaction with the state of criminology. The need for a new paradigm for the 21st century is clear. However, many distrust biology as a factor in studies of criminal behavior, whether because of limited exposure or because the orientation of criminology in general has a propensity to see it as racist, classist, or at least illiberal. This innovative new book by noted criminologist Anthony Walsh dispels such fears, examining how information from the biological sciences strengthens criminology work and both complements and improves upon traditional theories of criminal behavior. With its reasoned case for biological science as a fundamental tool of the criminologist, Walsh's groundbreaking work will be required reading for all students and faculty within the field of criminology.

Citizen Science
  • Language: en
  • Pages: 224

Citizen Science

  • Type: Book
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  • Published: 2013
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  • Publisher: NSTA Press

The editors of this book have a straightforward goal: to inspire you to engage your students through public collaboration in scientific research--also known as citizen science. The book is specifically designed to get you comfortable using citizen science to support independent inquiry through which your students can learn both content and process skills. Citizen Science offers you: Real-life case studies of classes that engaged in citizen science and learned authentic scientific processes and the habits of mind associated with scientific reasoning. Fifteen stimulating lessons you can use to build data collection and analysis into your teaching. Plenty of flexibility. You can use the lessons...

The Ocean of Churn
  • Language: en
  • Pages: 324

The Ocean of Churn

  • Type: Book
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  • Published: 2016-08-10
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  • Publisher: Penguin UK

Much of human history has played itself out along the rim of the Indian Ocean. In a first-of-its-kind attempt, bestselling author Sanjeev Sanyal tells the history of this significant region, which stretches across East Africa, the Middle East and the Indian subcontinent to South East Asia and Australia. He narrates a fascinating tale about the earliest human migrations out of Africa and the great cities of Angkor and Vijayanagar; medieval Arab empires and Chinese ‘treasure fleets’; the rivalries of European colonial powers and a new dawn. Sanjeev explores remote archaeological sites, ancient inscriptions, maritime trading networks and half-forgotten oral histories, to make exciting revel...

Routledge Handbook of Indian Cinemas
  • Language: en
  • Pages: 473

Routledge Handbook of Indian Cinemas

  • Type: Book
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  • Published: 2013-04-17
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  • Publisher: Routledge

India is the largest film producing country in the world and its output has a global reach. After years of marginalisation by academics in the Western world, Indian cinemas have moved from the periphery to the centre of the world cinema in a comparatively short space of time. Bringing together contributions from leading scholars in the field, this Handbook looks at the complex reasons for this remarkable journey. Combining a historical and thematic approach, the Handbook discusses how Indian cinemas need to be understood in their historical unfolding as well as their complex relationships to social, economic, cultural, political, ideological, aesthetic, technical and institutional discourses. The thematic section provides an up-to-date critical narrative on diverse topics such as audience, censorship, film distribution, film industry, diaspora, sexuality, film music and nationalism. The Handbook provides a comprehensive and cutting edge survey of Indian cinemas, discussing Popular, Parallel/New Wave and Regional cinemas as well as the spectacular rise of Bollywood. It is an invaluable resource for students and academics of South Asian Studies, Film Studies and Cultural Studies.