Mitochondria produce the chemical energy necessary for eukaryotic cell functions; hence mitochondria are an essential component of health, playing roles in both disease and aging. More than 80 human diseases and syndromes are associated with mitochondrial dysfunction; this book focuses upon diseases linked to these ubiquitous organelles. Accumulation of mitochondrial DNA damage results in mitochondrial dysfunction through two main pathways. Mutation in mitochondrial DNA causes diseases such as Kearns-Sayre syndrome and Pearson syndrome. Mutation in chromosomal DNA causes diseases such as Parkinson's disease and schizophrenia. These and many other diseases are reviewed in this book. Key Features Presents the detailed structure of mitochondria, mitochondrial function, roles of oxidants and antioxidants in mitochondrial dysfunction. Includes summary of both causes and effects of these diseases. Discusses current and potential future therapies for mitochondrial dysfunction diseases Explores a wide variety of diseases caused by dysfunctional mitochondria.
WE’VE ALL SEEN THE HEADLINES: The Pill That Can Prevent Cancer! A Guaranteed Way To Avoid Alzheimer’s Disease! The Food That Lowers Bad Cholesterol! BUT WHAT SHOULD WE BELIEVE? ONCE UPON A TIME, maintaining your health seemed relatively simple. But today we’re barraged by a never-ending array of conflicting medical advice. It’s all terribly confusing, and most of us aren’t sure what news we can trust and what we can ignore. Doctor Chopra Says offers a solution that will help you make the right decisions for your health. In this groundbreaking book, Dr. Sanjiv Chopra teams up with renowned cardiologist Dr. Alan Lotvin to give you the most cutting-edge medical research available. Doc...
India is the largest film producing country in the world and its output has a global reach. After years of marginalisation by academics in the Western world, Indian cinemas have moved from the periphery to the centre of the world cinema in a comparatively short space of time. Bringing together contributions from leading scholars in the field, this Handbook looks at the complex reasons for this remarkable journey. Combining a historical and thematic approach, the Handbook discusses how Indian cinemas need to be understood in their historical unfolding as well as their complex relationships to social, economic, cultural, political, ideological, aesthetic, technical and institutional discourses. The thematic section provides an up-to-date critical narrative on diverse topics such as audience, censorship, film distribution, film industry, diaspora, sexuality, film music and nationalism. The Handbook provides a comprehensive and cutting edge survey of Indian cinemas, discussing Popular, Parallel/New Wave and Regional cinemas as well as the spectacular rise of Bollywood. It is an invaluable resource for students and academics of South Asian Studies, Film Studies and Cultural Studies.
For those preparing for certification or recertification in hematology or oncology, Hoffman and Abeloff's Hematology-Oncology Review is a single-volume source of authoritative, up-to-date exam preparation. This unique question and answer review helps you succeed on today’s board exams with more than 1,000 board-style questions, answers, and rationales; comprehensive coverage of essential exam topics, and online practice tests. Includes 1,000+ board-style questions with answers and rationales explaining both correct and incorrect answers. Covers a broad range of topics compiled by experts in hematology and oncology, including cancer biology and genomics, immunotherapy, hematologic malignancies, solid tumor malignancies, non-malignant hematology, and supportive care. Uniquely designed as both a standalone review and a study companion to Abeloff’s Clinical Oncology and Hematology: Basic Principles and Practice.
Reporter genes have been used for several decades to study regulation of gene expression in vivo. However, it was little more than a decade ago that a new class of reporter genes was developed for imaging molecular events within living subjects. By following the interactions of protein molecules, researchers can resolve the complex chemical pathways that living cells utilise. This book focuses on this group of imaging reporter genes, starting with detailed descriptions of all reporter genes from different imaging modalities, including optical, MRI, and radionuclide-based imaging. Key scientists in the field explain how to enhance reporter gene imaging utility through instrumentation and the various applications of this technology. This is the first comprehensive book on all aspects of reporter gene imaging, detailing what is known in the field and future goals for research. Investigators in biomedical sciences, physicians, and the biotechnology and pharmaceutical industries will benefit from topics covered.
An accessible and inspiring guide to good leadership based on a popular lecture that Dr. Chopra has presented to thousands Very few of us are leaders all the time, in everything we do, but all of us can become a leader in specific situations. In a committee, in business, at a social club or at a religious institution, we all find a time in our lives when we can lead. Few people set out knowingly to become leaders, rather they see a need and they find a way of dealing with it, and often others choose to follow their example. Based on a talk that he has given to more than 60,000 people in at least seven countries, the "LEADERSHIP" mnemonic that Dr. C hopra explains is as follows: L - listen we...
Numerous criminologists have noted their dissatisfaction with the state of criminology. The need for a new paradigm for the 21st century is clear. However, many distrust biology as a factor in studies of criminal behavior, whether because of limited exposure or because the orientation of criminology in general has a propensity to see it as racist, classist, or at least illiberal. This innovative new book by noted criminologist Anthony Walsh dispels such fears, examining how information from the biological sciences strengthens criminology work and both complements and improves upon traditional theories of criminal behavior. With its reasoned case for biological science as a fundamental tool of the criminologist, Walsh's groundbreaking work will be required reading for all students and faculty within the field of criminology.
Traces the lives of the Chopra brothers from India to America, where they both excelled in healing, one as a world-renowned spiritual teacher, the other as a professor at Harvard Medical School. 100,000 first printing.
The editors of this book have a straightforward goal: to inspire you to engage your students through public collaboration in scientific research--also known as citizen science. The book is specifically designed to get you comfortable using citizen science to support independent inquiry through which your students can learn both content and process skills. Citizen Science offers you: Real-life case studies of classes that engaged in citizen science and learned authentic scientific processes and the habits of mind associated with scientific reasoning. Fifteen stimulating lessons you can use to build data collection and analysis into your teaching. Plenty of flexibility. You can use the lessons...
It has been the authors' experience that the overwhelming majority of students in MBA derivatives courses go on to careers where a deep conceptual, rather than solely mathematical, understanding of products and models is required. The first edition of Derivatives looks to create precisely such a blended approach, one that is formal and rigorous, yet intuitive and accessible. The main body of this book is divided into six parts. Parts 1-3 cover, respectively, futures and forwards; options; and swaps. Part 4 examines term-structure modeling and the pricing of interest-rate derivatives, while Part 5 is concerned with credit derivatives and the modeling of credit risk. Part 6 discusses computational issues.