Reporter genes have been used for several decades to study regulation of gene expression in vivo. However, it was little more than a decade ago that a new class of reporter genes was developed for imaging molecular events within living subjects. By following the interactions of protein molecules, researchers can resolve the complex chemical pathways that living cells utilise. This book focuses on this group of imaging reporter genes, starting with detailed descriptions of all reporter genes from different imaging modalities, including optical, MRI, and radionuclide-based imaging. Key scientists in the field explain how to enhance reporter gene imaging utility through instrumentation and the various applications of this technology. This is the first comprehensive book on all aspects of reporter gene imaging, detailing what is known in the field and future goals for research. Investigators in biomedical sciences, physicians, and the biotechnology and pharmaceutical industries will benefit from topics covered.
The field of molecular imaging of living subjects have evolved considerably and have seen spectacular advances in chemistry, engineering and biomedical applications. This textbook was designed to fill the need for an authoritative source for this multi-disciplinary field. We have been fortunate to recruit over 80 leading authors contributing 75 individual chapters. Given the multidisciplinary nature of the field, the book is broken into six different sections: "Molecular Imaging technologies", "Chemistry", "Molecular Imaging in Cell and Molecular Biology", "Applications of Molecular Imaging", "Molecular Imaging in Drug Evaluation" with the final section comprised of chapters on computation, bioinformatics and modeling. The organization of this large amount of information is logical and strives to avoid redundancies among chapters. It encourages the use of figures to illustrate concepts and to provide numerous molecular imaging examples.
An internationally recognized team of editors and contributors present an authoritative, state-of-the-art reference on nuclear medicine and its clinical applications. They focus on helping the reader to solve the challenges encountered in day-to-day practice, including image interpretation, image optimization techniques, and pitfalls in image acquisition and interpretation. Over 4,400 illustrations, 803 in full color, comprise a comprehensive visual guide to interpretation. This new edition also incorporates three brand-new, full-color atlases-PET and PET/CT, SPECT and SPECT/CT, and a PET brain atlas-as well as many new full-color images (more than 800 in all)! Completely revised and thoroug...
This text will help the reader gain a basic understanding of the complexity of molecular imaging. The book will be an easy-to-read primer for practicing radiologists, nuclear medicine practitioners, and residents in radiology and nuclear medicine who want to learn more about the emerging field of molecular imaging (using PET, SPECT, MRI, and CT). Dr. Gambhir will present to the reader a solid overview on the instrumentation, molecular biology, assays, and the clinical applications currently existing. Each of the chapters will be heavily illustrated with clear imaging examples of the principles discussed throughout. In-depth coverage on frequently asked questions and the future of molecular imaging will be thoroughly discussed as well; plus, every concept will be defined in a detailed glossary. With its tremendous diagnostic and staging capabilities, and potential benefits to patients, molecular imaging is clearly the way of the future in radiology.
This book is written as both a text and a reference book. It contains numerous images from the biological sciences and clinical practice, tables, graphs, and fig ures, as well as exercises that are worked out to aid the reader in understanding principles or solving problems. In some cases, derivations are placed in appen dices so as not to break up the flow of the subject matter in the text. The book is intended for a broad audience interested in molecular imaging with positron emission tomography (PET). It is expected that the readers will range from undergraduate, graduate, and medical students to residents, physi cians, and scientists with backgrounds from various physical, biological, an...
2nd edition - totally updated and revised. Provides the latest update on procedures in nuclear medicine. Documents the role of PET in oncology and introduces dual modality imaging with PET/CT. Includes sections on molecular imaging and future prospects. Represents an adjunct to standard knowledge of diagnostic nuclear medicine.
This book is a compilation of reviews about the pathogenesis of Type 1 Diabetes. T1D is a classic autoimmune disease. Genetic factors are clearly determinant but cannot explain the rapid, even overwhelming expanse of this disease. Understanding etiology and pathogenesis of this disease is essential. A number of experts in the field have covered a range of topics for consideration that are applicable to researcher and clinician alike. This book provides apt descriptions of cutting edge technologies and applications in the ever going search for treatments and cure for diabetes. Areas including T cell development, innate immune responses, imaging of pancreata, potential viral initiators, etc. are considered.
For all the talk about personalized medicine, our health care system remains a top-down, doctor-driven system where individuals are too often bit players in their own health decisions. In The Decision Tree, Thomas Goetz proposes a new strategy for thinking about health, one that applies cutting-edge technology to put us at the center of the equation and explains how the new frontier of health care can impact each of our lives.
This is the first book entirely dedicated to Intravital Microscopy. It provides the reader with a broad overview of the main applications of Intravital Microscopy in various areas of the biomedical field. The book contains accurate descriptions of the state of the art methodologies used to image various organs at different level of resolution, ranging from whole tissue down to sub-cellular structures. Moreover, it is an extremely valuable guide to scientists that want to adopt this powerful technique and do not have experience with animal models and microscopy.
Essential for students, science and medical graduates who want to understand the basic science of Positron Emission Tomography (PET), this book describes the physics, chemistry, technology and overview of the clinical uses behind the science of PET and the imaging techniques it uses. In recent years, PET has moved from high-end research imaging tool used by the highly specialized to an essential component of clinical evaluation in the clinic, especially in cancer management. Previously being the realm of scientists, this book explains PET instrumentation, radiochemistry, PET data acquisition and image formation, integration of structural and functional images, radiation dosimetry and protect...